WASHINGTON — Responding to sharp criticism from Republicans for his work on housing discrimination and voting rights at the Justice Department, Thomas E. Perez, President Obama’s choice to head the Labor Department, on Thursday defended his record and said that if confirmed, his focus would be on tackling the nation’s high unemployment rate. Senator Lamar Alexander of Tennessee, the ranking Republican on the labor committee, cited a scathing report from other Republican lawmakers as he questioned Mr. Perez about a deal he helped broker with officials in St. Paul for the city to drop a housing discrimination lawsuit in exchange for the Justice Department’s declining to join two whistle-blower complaints against the city. “That seems to me to be an extraordinary amount of wheeling and dealing outside the normal responsibilities of the assistant attorney general for civil rights,” Mr. Alexander said. He later added that he expected Mr. Perez to respond in full to a subpoena from Representative Darrell Issa of California, chairman of the House Oversight Committee, for personal e-mails believed to contain more information about the deal. Mr. Perez countered that not only had he sought the guidance of ethics experts on the agreement, his had not been the final word. “The senior career people in the civil division kicked the tires on this case. They looked at it very carefully, they made a very considered judgment that it was a weak case,” he said. Democrats were eager to voice their support for Mr. Perez, who, if confirmed would be the only Hispanic member of the cabinet. Anticipating questions about the deal, Senator Tom Harkin of Iowa, the committee chairman, opened the questioning by leading Mr. Perez through a series of largely yes-or-no queries designed to rebut the Republican report. “As I said, we have gone through this with a fine-tooth comb, with our lawyers, with our staff,” Mr. Harkin said. “And everything I can see is that you acted appropriately and ethically to advance the interests of the United States.” Questioning the role of politics in Mr. Perez’s challenges to voting laws, Senator Tim Scott, Republican of South Carolina, brought up the Justice Department’s move to block that state’s voter identification law in 2011 on the grounds that it would discourage minority voters. “As I look at your management style, it seems to have a political perspective, a political bias in the management style,” Mr. Scott said. “It seems not to be open and not to be balanced and certainly not to be fair.” Senator David Vitter, Republican of Louisiana, released a statement in March vowing to block Mr. Perez’s nomination pending a response from the Justice Department on his accusations of uneven enforcement of voter registration rights in his state. As expected, many of the questions focused on job creation, with senators from both parties asking about his commitment to the Job Corps, a training program for young people, among others. “Jobs, jobs, and jobs,” Mr. Perez said, summing up his top priority as labor secretary. “I believe it’s critically important to get Americans back to work, and I believe the Department of Labor can play a critical role.” The committee plans to take up the nomination again next week.