María Belén Chapur’s appearance was a surprise, especially to leaders in the national Republican Party. It might not have been the most strategic move in Mr. Sanford’s attempt at a political comeback. Still, it was how Mr. Sanford wanted it. Whether national Republican leaders will decide that the former governor is putting the seat in jeopardy and decide to lend more support is only one question in a race that has already been filled with political and personal drama. After defeating 15 other candidates in a primary race and winning a runoff on Tuesday, Mr. Sanford faces Elizabeth Colbert Busch, a Democrat with enough celebrity appeal and financial backing to change what could have been an easy victory in the special election on May 7 into a real battle. “Everybody is really concerned because she’s not a bad-looking lady, she is a good speaker and she’s got some money,” said Jerry Hallman, chairman of the Beaufort County Republican Party. “In politics, those things are important.” The seat became vacant after Senator Jim DeMint announced in December that he was stepping down to take over the Heritage Foundation. Gov. Nikki R. Haley appointed Representative Tim Scott to replace him, opening up the Congressional seat that Mr. Sanford held before he became governor. Gender, fidelity and experience are already shaping up as themes in the district, which includes Charleston, Hilton Head and some Low Country farmland. Mr. Sanford began his campaign as a kind of apology tour, explaining he had learned much about humility after leaving the governor’s office in 2011, having lied about a trip to Argentina to visit Ms. Chapur. Mr. Sanford said he was hiking the Appalachian Trail. Although he finished his term, he faced ethics fines, censure by his party and divorce from his wife of 21 years, Jenny. Now, he has gone on the offensive, portraying himself as a seasoned fiscal hawk in a race against a political neophyte whose most notable credential is her celebrity family. Ms. Colbert Busch’s younger brother is the comedian Stephen Colbert, who has been active in her campaign. Already the national Republican Party, though not committing to using heavy artillery in the race, is painting Ms. Colbert Busch as too liberal for a district that voted for Mitt Romney in the presidential primary. (Newt Gingrich won the state over all.) “So far, Elizabeth Colbert Busch has yet to answer any real questions about why she supports President Obama’s failed policies,” said Katie Prill, a spokeswoman for the National Republican Congressional Committee. “She might be the gem of the Beltway and Hollywood liberals, but South Carolinians are going to be sorely disappointed the more they learn about her.” Ms. Colbert Busch is leaning on her years as a maritime executive and at Clemson University, where she is leading an effort to develop the state’s wind power industry. She is also relying on several women in Congress, among them Senator Kirsten E. Gillibrand, the New York Democrat, who began using Twitter to seek donations to the campaign. Democratic leaders realize the race must be run without error, with special attention paid to women and moderate Republicans who remember Mr. Sanford’s rocky relationship with the Legislature when he was in office and, of course, his affair. But the national organization probably won’t make a move until the other side does. “This is a Republican seat in a Republican district, so we’ll wait and see what the Republicans do,” said Jesse Ferguson of the Democratic Congressional Campaign Committee. Hesaid national Republican organization might not be eager to get involved. “Having Mark Sanford as the face of the party is probably not the best thing for a party trying to rehabilitate itself with women voters,” he said.